Deep neural networks have demonstrated susceptibility to adversarial attacks. Adversarial defense techniques often focus on one-shot setting to maintain robustness against attack. However, new attacks can emerge in sequences in real-world deployment scenarios. As a result, it is crucial for a defense model to constantly adapt to new attacks, but the adaptation process can lead to catastrophic forgetting of previously defended against attacks. In this paper, we discuss for the first time the concept of continual adversarial defense under a sequence of attacks, and propose a lifelong defense baseline called Anisotropic \& Isotropic Replay (AIR), which offers three advantages: (1) Isotropic replay ensures model consistency in the neighborhood distribution of new data, indirectly aligning the output preference between old and new tasks. (2) Anisotropic replay enables the model to learn a compromise data manifold with fresh mixed semantics for further replay constraints and potential future attacks. (3) A straightforward regularizer mitigates the 'plasticity-stability' trade-off by aligning model output between new and old tasks. Experiment results demonstrate that AIR can approximate or even exceed the empirical performance upper bounds achieved by Joint Training.