Generative Adversarial Networks (GANs) have been widely used to recover vivid textures in image super-resolution (SR) tasks. In particular, one discriminator is utilized to enable the SR network to learn the distribution of real-world high-quality images in an adversarial training manner. However, the distribution learning is overly coarse-grained, which is susceptible to virtual textures and causes counter-intuitive generation results. To mitigate this, we propose the simple and effective Semantic-aware Discriminator (denoted as SeD), which encourages the SR network to learn the fine-grained distributions by introducing the semantics of images as a condition. Concretely, we aim to excavate the semantics of images from a well-trained semantic extractor. Under different semantics, the discriminator is able to distinguish the real-fake images individually and adaptively, which guides the SR network to learn the more fine-grained semantic-aware textures. To obtain accurate and abundant semantics, we take full advantage of recently popular pre-trained large vision models (LVMs) with a large dataset, and then incorporate its semantic features into the discriminator through a well-designed spatial cross-attention module. In this way, our proposed semantic-aware discriminator empowered the SR network to produce more photo-realistic and pleasing images. Extensive experiments on two typical tasks, i.e., SR and Real SR have demonstrated the effectiveness of our proposed methods.