It is important to quantify the uncertainty of input samples, especially in mission-critical domains such as autonomous driving and healthcare, where failure predictions on out-of-distribution (OOD) data are likely to cause big problems. OOD detection problem fundamentally begins in that the model cannot express what it is not aware of. Post-hoc OOD detection approaches are widely explored because they do not require an additional re-training process which might degrade the model’s performance and increase the training cost. In this study, from the perspective of neurons in the deep layer of the model representing high-level features, we introduce a new aspect for analyzing the difference in model outputs between in-distribution data and OOD data. We propose a novel method, Leveraging Important Neurons (LINe), for post-hoc Out of distribution detection. Shapley value-based pruning reduces the effects of noisy outputs by selecting only high-contribution neurons for predicting specific classes of input data and masking the rest. Activation clipping fixes all values above a certain threshold into the same value, allowing LINe to treat all the class-specific features equally and just consider the difference between the number of activated feature differences between in-distribution and OOD data. Comprehensive experiments verify the effectiveness of the proposed method by outperforming state-of-the-art post-hoc OOD detection methods on CIFAR-10, CIFAR-100, and ImageNet datasets.