Recently, CLIP has been applied to pixel-level zero-shot learning tasks via a wo-stage scheme. The general idea is to first generate class-agnostic region proposals and then feed the cropped proposal regions to CLIP to utilize its image-level zero-shot classification capability. While effective, such a scheme requires two image encoders, one for proposal generation and one for CLIP, leading to a complicated pipeline and high computational cost. In this work, we pursue a simpler-and-efficient one-stage solution that directly extends CLIP’s zero-shot prediction capability from image to pixel level. Our investigation starts with a straightforward extension as our baseline that generates semantic masks by comparing the similarity between text and patch embeddings extracted from CLIP. However, such a paradigm could heavily overfit the seen classes and fail to generalize to unseen classes. To handle this issue, we propose three simple-but-effective designs and figure out that they can significantly retain the inherent zero-shot capacity of CLIP and improve pixel-level generalization ability. Incorporating those modifications leads to an efficient zero-shot semantic segmentation system called ZegCLIP. Through extensive experiments on three public benchmarks, ZegCLIP demonstrates superior performance, outperforming the state-of-the-art methods by a large margin under both “inductive” and “transductive” zero-shot settings. In addition, compared with the two-stage method, our one-stage ZegCLIP achieves a speedup of about 5 times faster during inference. We release the code at https://github.com/ZiqinZhou66/ZegCLIP.git.